Human vaccines are used for infectious diseases to increase the immunization rate of the host organism and helps in eradicating the disease from the population. It is the most effective preventative measure against infectious diseases. Some vaccines offer lifelong immunity. In other cases, booster shots are needed in the form of vaccination. Vaccines trick the body into build immunity against infectious diseases without causing the actual disease. Vaccines achieve this by introducing a dead or weakened version of the disease-causing germs (bacteria or virus) to the body’s immune system. After vaccination, if our immune system encounters the ‘real’ disease-causing germ, quick recognition allows our body to fight infection or neutralize toxins with a rapid and effective immune response. To generate vaccine-mediated protection is a complex challenge. Currently available vaccines have largely been developed empirically, with little or no understanding of how they activate the immune system. Their early protective efficacy is primarily conferred by the induction of antigen-specific antibodies. However, there is more to antibody-mediated protection than the peak of vaccine-induced antibody titers.